Vol. 1, 2016

Original research papers

Biophysics

OPTICAL CORE-SHELL MODEL FOR NANO-DELIVERY APPLICATIONS

Ana J. Šetrajčić – Tomić , Dušan Lj. Džambas , Ljubiša D. Džambas , Jovan P. Šetrajčić

Pages: 165-170

DOI: 10.21175/RadProc.2016.39

In this paper, we will analyze the application of nanomaterials in biomedicine, that is to say, we will present the recent accomplishments in basic and clinical nanomedicine. Achieving the full potential of nanomedicine may be years or even decades away; however, potential advances in drug delivery, diagnosis, and the development of nanotechnology-related drugs are starting to change the landscape of medicine. Site-specific targeted drug delivery (made possible by the availability of unique delivery platforms, such as dendrimers, nanoparticles and nanoliposomes) and personalized medicine (result of the advance in pharmacogenetics) are just a few concepts on the horizon of research. In this paper, we have especially analyzed the changes in basic physical properties of spherical-shaped nanoparticles that can be made in several (nano)layers and have, at the same time, multiple applications in medicine. The subject of the research in this paper includes the modeling of nanomaterials in the field of pharmaceutical technology for biomedical application. This includes a very precise encapsulated drug delivery on the exactly defined place in the human tissue or organ and the disintegration of the capsule – drug carrier, so that the medicament can start producing its effect. The goal of multidisciplinary researches with biocompatible molecular nanomaterials is to find the parameters and the possibilities to construct boundary surfaces that will, in interaction with the biological environment, create such properties of nanolayers that can be conveniently used for layers of drug carrier capsules, biochips and biomarkers. These layers should demonstrate a controlled disintegration of structure, better dielectric properties, discrete luminescence and appropriate bioporosity, as all of these are the requirements of contemporary nanomedicine.
  1. K.J. Morrow, R.Bawa, C. Wei, “Recent Advances in Basic and Clinical Nanomedicine,” Med .Clin. N. Am., vol. 91, no. 5, pp. 805-843, 2007
    DOI: 10.1016/j.mcna.2007.05.009
  2. Drug Delivery Nanoparticles – Formulation and Characterization, vol. 191, Y. Pathak, D. Thassu, Eds., New York (NY), USA: Informa Healthcare, 2009
  3. H.E. Schaefer, Nanoscience – The Science of the Small in Physics, Engineering, Chemistry, Biology and Medicine, Berlin, Germany: Springer, 2010
  4. M.A. Greenwood, “Are Quantum Dots on the Brink of Their Big Break?” Phot. Spectra, May 2007
  5. E.A. Murphy et al., “Nanoparticle-Mediated Drug Delivery to Tumor Vasculature Suppresses Metastasis,” PNAS, vol. 105, no.27, pp. 9343-9348, 2008
    DOI: 10.1073/pnas.0803728105
  6. W.C.W. Chan, “Bionanotechnology Progress and Advances,” Biol. Blood Marr. Transpl., vol.12, no. 1, suppl. 1, pp. 87-91, Jan 2006
    DOI: 10.1016/j.bbmt.2005.10.004
  7. Y. Pathak, “Recent Developments in Nanoparticulate Drug Delivery Systems,” in Drug Delivery Nanoparticles – Formulation and Characterization, vol. 191, Y. Pathak, D. Thassu, Eds., New York (NY), USA: Informa Healthcare, 2009, sec. 1, pp. 1-15
  8. H. Devapally, A. Chakilam, M.M. Amiji, “Role of Nanotechnology in Pharmaceutical Development,” J. Pharm. Sci., vol. 96, no. 10, pp. 2547–2565, Oct. 2007
    DOI: 10.1002/jps.20875
  9. J.P. Šetrajčić, “Exact Microtheoretical Approach to Calculation of Optical Properties of Ultralow Dimensional Crystals,” arXiv:cond-mat/eprint: 1004.2387 (Cornell Univ. Lib.), Apr. 2010
  10. J.P. Šetrajčić et al., “Absorption Features of Symmetric Molecular Nanofilms,” in Proceedings 27th MIEL, Niš, Serbia, 2010, pp. 127-130
    DOI: 10.1109/MIEL.2010.5490518
  11. S.Y. Quek, J.B. Neaton, M.S. Hybertsen, E. Kaxiras and S.G. Louie, “First-principles Studies of the Electronic Structure of Cyclopentene on Si(001): Density Functional Theory and GW Calculations,” Phys. Stat. Solidi (b), vol. 243, no. 9, 2048-2053, July 2006
    DOI: 10.1002/pssb.200666819
  12. G. Samsonidze, M. Jain, J. Deslippe, M.L. Cohen and S.G. Louie, “Simple approximate Physical Orbitals for GW Quasiparticle Calculations,” Phys. Rev. Lett., vol. 107, p. 186404, Oct. 2011
    DOI: 10.1103/PhysRevLett.107.186404
  13. J. Deslippe, G. Samsonidze, D.A. Strubbe, M. Jain, M.L. Cohen and S.G. Louie, “BerkeleyGW: A Massively Parallel Computer Package for the Calculation of the Quasiparticle and Optical Properties of Materials and Nanostructures,” Comput. Phys. Commun., vol. 183, no. 6 pp. 1269-1289, June 2012
    DOI: 10.1016/j.cpc.2011.12.006
  14. G. Mahan, Many-Particle Physics, 2nd ed., New York (NY), USA: Plenum Press, 1990
    DOI: 10.1007/978-1-4613-1469-1
  15. J.P. Šetrajčić et al., “Phonon Contribution in Thermodynamics of Nano-Crystalline Films and Wires,” Acta Phys .Pol. A, vol. 115, no. 4, pp. 778-782, 2009
    DOI: 10.12693/APhysPolA.115.778
  16. S.M. Stojković, D.Lj. Mirjanić, J.P. Šetrajčić, D.D. Šijačić, I.K. Junger, “Spectra and States of Electrons in Surface Perturbed Quantum Wires,” Surf. Sci., vol. 477, no. 2-3, pp. 235-242, Apr. 2001
    DOI: 10.1016/S0039-6028(01)00887-1
  17. D.I. Ilić, S.M. Vučenović, S.K. Jaćimovski, V.M. Zorić and J.P. Šetrajčić, “Phonon Spectra and Thermodynamics of Crystalline Nanowires,” in Low-Dimensional Materials Synthesis, Assembly, Property Scaling, and Modeling, vol. 50, M. Shim, M. Kuno, X-M. Lin, R. Pachter and S. Kumar, Eds., San Francisco (CA), USA: Materials Res. Soc., 2007, pp. 1-6
  18. I.D. Vragović, J.P. Šetrajčić and R. Scholz, “Quantum Size Effects in the Optical Properties of Organic Superlattices Containing 3,4,9,10 PTCDA,” Eur. Phys. J. B, vol. 66, no. 2, pp. 185-190, Nov. 2008
    DOI: 10.1140/epjb/e2008-00409-1
  19. G. Samsonidze, F.J. Ribeiro, M.L. Cohen, and S.G. Louie, “Quasiparticle and Optical Properties of Polythiophene-Derived Polymers,” Phys.Rev.B, vol. 90, no. 3, p. 035123, July 2014
    DOI: 10.1103/PhysRevB.90.035123
  20. Lj. Mirjanić, J.P. Šetrajčić, Lj. D.Džambas, V.D. Mirjanić, A.J. Šetrajčić-Tomić and V.M. Zorić, “Nanoscopic Bio­materials in Medicine, Dentistry and Pharmacy,” in Procced. 10th Int. Sci.-Practical Conf. "Research, Development and Application of High Technologies in Industry", Saint-Petersburg, Russia, 2010, pp. 97-107
  21. J.P. Šetrajčić, D.Lj. Mirjanić, A.J. Šetrajčić-Tomić, S. Armaković and I.J. Šetrajčić, “Core-Shell Nanomodels for Biomedical Applications,” in Proceed. Int. Conf. New Face of TMCR: Modern Techn., Quality and Innov., Vadul lui Voda, Moldova, 2011, pp. 545-548
  22. J.P. Šetrajčić, A.J. Šetrajčić–Tomić, Lj.D. Džambas and I. Gušić, “Core-Shell Layered Models of Nanostructured Carriers for a Nano-Bio-Medical Applications,” in Proceed. 3rd RAD, Budva, Montenegro, 2015, pp. 487-494