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ASSESSING THE ROLE OF VMAT RELATIVE TO IMRT FOR PATIENTS AFTER PROSTATECTOMY IN TERMS OF SPARING PELVIC BONES
Maria Poncyljusz, Wojciech Bulski
Pages: 72–75
DOI: 10.21175/RadProc.2020.15
Abstract |
References | Cite This | Full Text (PDF)
For postprostatectomy patients at higher risk of nodal involvement the irradiation of pelvic lymph nodes may improve the therapeutic ratio. However, whole pelvic radiotherapy results in increased doses delivered to the pelvic bones’ marrow and other OARs. The aim of this study was to compare IMRT and VMAT techniques in terms of sparing of pelvic bones. The VMAT and IMRT plans were created for ten patients. Treatment plans were generated for prostate bed (PTV1) and pelvic lymph nodes (PTV2). The delivered mean dose to the sum of PTV1 and PTV2 was 46Gy in 23 fractions and additionally a mean dose of 18Gy in 9 fractions was prescribed to PTV1. The target coverage and the OARs sparing were compared across techniques. The following OARs were delineated: pelvic bones, bowel bag, rectum and bladder. The following dose volume parameters were compared using the Wilcoxon test: pelvic bones V30Gy[%], V40Gy[%], the bowel bag V30Gy[cc], V45Gy[cc], rectum V40Gy[%], V50Gy[%], V60Gy[%] and bladder V40Gy[%], V50Gy[%], V60Gy[%]. The target coverage in VMAT and IMRT plans was comparable. The value of PTV1 V95% and PTV2 V95% were both >99%. The VMAT plans result in decrease of pelvic bones V30Gy[%] and significant increase of the following parameters: rectum V60Gy[%], bladder V60Gy[%] and bowel bag V30Gy[cc]. Differences between values of V40Gy[%] and V50Gy[%] for bladder and rectum across mentioned techniques were statistically not significant. A comparison between VMAT and IMRT techniques showed, that the VMAT technique reduces the delivered dose to pelvic bones and thus also to red marrow. However, IMRT provided better sparing at higher doses for rectum, bladder and bowel bag. These results should be taken into consideration when VMAT and IMRT techniques being used in the whole pelvic radiotherapy of patients after radical prostatectomy.
- M.T. Spiotto, S.L. Hancock, C.R. King, “Radiotherapy after prostatectomy: improved biochemical relapse-free survival with whole pelvic compared with prostate bed only for high-risk patients,” Int. J. Radiat. Oncol. Biol. Phys., vol. 69, no.1, pp. 54–61, Sep. 2007.
DOI: 10.1016/j.ijrobp.2007.02.035 PMid: 17459606 - C. Sini, C. Fiorino, L. Perna, et al. “Dose–volume effects for pelvic bone marrow in predicting haematological toxicity in prostate cancer radiotherapy with pelvic node irradiation,” Radiother. Oncol., vol. 118, no.1, pp. 79–84, Jan. 2016.
DOI: 10.1016/j.radonc.2015.11.020 PMid: 26702990 - Ch. Kusumoto, S. Ohira, M. Miyazaki, et al. “Effect of various methods for rectum delineation on relative and absolute dose-volume histograms for prostate IMRT treatment planning,” Medical Dosimetry, vol. 41, no. 2, pp. 136–141, Jun. 2016.
DOI: 10.1016/j.meddos.2015.11.001 - S. Sutani, T. Ohashi, M. Sakayori, et al. “Comparison of genitourinary and gastrointestinal toxicity among four radiotherapy modalities for prostate cancer: Conventional radiotherapy, intensity-modulated radiotherapy, and permanent iodine-125 implantation with or without external beam radiotherapy,” Radiother. Oncol., vol. 117, no.2, pp. 270–276, Nov. 2015.
DOI: 10.1016/j.radonc.2015.08.019 PMid: 26318662 - 5. C. J. Neill, “Dosimetric comparison of intensity-modulated solutions for intact prostate cancer,” Medical Dosimetry, vol. 39, no. 4, pp. 366–373, 2014.
DOI: 10.1016/j.meddos.2014.06.006 - E. A. Mellon, K. Javedan, T. J. Strom, et al. “A dosimetric comparison of volumetric modulated arc therapy with step-and-shoot intensity modulated radiation therapy for prostate cancer,” Practical Radiation Oncology, vol. 5, no. 1, pp. 11-15, Jan. 2015.
DOI: 10.1016/j.prro.2014.03.003 PMid: 25413432 - R. Wortel, L. Incrocci, F. Pos, et al. “Image-guided IMRT reduces late toxicity compared to 3D-CRT for prostate cancer,” Radiother. Oncol., vol. 119, pp. S346-S347, Apr. 2016.
DOI: 10.1016/S0167-8140(16)31992-2 - H. E. Carter, A. Martin, D. Schofield, et al. “A decision model to estimate the cost-effectiveness of intensity modulated radiation therapy (IMRT) compared to three dimensional conformal radiation therapy (3DCRT) in patients receiving radiotherapy to the prostate bed,” Radiother. Oncol., vol. 112, no. 2, pp. 187-193, Aug. 2014.
DOI: 10.1016/j.radonc.2014.03.020 PMid: 24929702 - S. Katayama, T. Striecker, K. Kessel, et al. “Hypofractionated IMRT of the prostate bed after radical prostatectomy: acute toxicity in the PRIAMOS-1 Trial,” Radiother. Oncol., vol. 90, no.4, pp. 926-933, Nov. 2014.
DOI: 10.1016/j.ijrobp.2014.07.015 PMid: 25216858 - M. Davidson, S. Blake, D. Batchelar, et al. “Assessing the role of volumetric modulated arc therapy (VMAT) relative to IMRT and helical tomotherapy in management of localized, locally advanced, and post-operative prostate cancer,” Int. J. Radiat. Oncol. Biol. Phys., vol. 80, no. 5, pp. 1550-1558, Aug. 2011.
DOI: 10.1016/j.ijrobp.2010.10.024 PMid: 21543164 - H. A. Gay, H. J. Barthold, E. O’Meara et al. “Pelvic Normal Tissue Contouring Guidelines for Radiation Therapy: A Radiation Therapy Oncology Group Consensus Panel Atlas,” J. Radiat. Oncol. Biol. Phys., vol. 83, no. 3, pp. E353-E362, Jul. 2012.
DOI: 10.1016/j.ijrobp.2012.01.023 - L. B. Marks, E. D. Yorke, A. Jackson, et al. “Use of normal tissue complication probability models in the clinic,” Int. J. Radiat. Oncol. Biol. Phys., vol. 76, no. 3, pp. S10-S19, Mar. 2010.
DOI: 10.1016/j.ijrobp.2009.07.1754 PMid: 20171502 PMCid: PMC4041542 - L. K. Mell, D. A. Schomas, J. K. Salama, et al. “Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patient treated with concurrent chemotherapy and intensity-modulated radiotherapy,” Int. J. Radiat. Oncol. Biol. Phys., vol. 70, no. 5, pp. 1431-1437, Apr. 2008.
DOI: 10.1016/j.ijrobp.2007.08.074 PMid: 17996390 - F. Alongi, C. Fiorino, C. Cozzarini, et al. “IMRT significantly reduces acute toxicity of whole-pelvis irradiation in patients treated with post-operative adjuvant or salvage radiotherapy after radical prostatectomy,” Radiother. Oncol., vol. 93, no. 2, pp. 207–212, Nov. 2009.
DOI: 10.1016/j.radonc.2009.08.042
Maria Poncyljusz, Wojciech Bulski, "Assessing the role of VMAT relative to IMRT for patients after prostatectomy in terms of sparing pelvic bones," RAD Conf. Proc, vol. 4, 2020, pp. 72–75, http://doi.org/10.21175/RadProc.2020.15
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