Vol. 2, 2017



L.I. Korytova, E.A.Maslyukova, A.V. Bondarenko, O.V.Korytov, E.M.Muravnik

Pages: 181-184

DOI: 10.21175/RadProc.2017.37

Lowest dose detection per ipsilateral lung versus various dosimetric irradiation plans for the left mammary gland is investigated. The study involves dosimetric radiotherapeutic (RT) plans of 20 female patients with left BC (breast cancer). Pre-irradiation preparation included 3 sessions of CT scan: patient in standard dorsal position with tidal respiration (STR), in dorsal position with controlled breathhold on top inspiration (DBH) and in prone position with tidal respiration (PTR). Three CT-sessions were followed by 3D-plan dosimetric calculations. Dose-volumetric measures for organs at risk (OAR) were assessed for every irradiation option. Contoured left lung volume in all studied variants varied within 757.1 cm3 – 2923.8 cm3, mean volume 1751.6 cm3. The best values, such as V25lung (when α/β=3.1) and V28lung (when α/β=9), average doses per ipsilateral lung were received using the PTR method (V25lung (α/β=3.1) – 10.19%, V28lung (α/β=9) – 9.19%; Dmean lung 7.42 Gy) versus the STR method (V25lung (α/β=3.1) – 20.72%, V28lung (α/β=9) – 19.6%; D mean 10.42 Gy) and DBH-position (V25lung (α/β=3.1) – 20.17%, V28lung (α/β=9) – 19.01%; Dmean lung 10.11 Gy) included in MG volume and axillary LN with V25lung (α/β=3.1) - Р=0.00000**, V28lung (α/β=9) – Р=0.00000**; D mean - p=0.00002**. No preferences in dosimetry were detected for the addition of supraclavicular and infraclavicular lymph nodes (LN) in irradiation volume using STR and DBH methods: DBH (V25lung (α/β=3.1) – 21.49%, V28lung (α/β=9) – 20.17%; Dmean lung 10.85 Gy) versus STR method (V25lung (α/β=3.1) – 23.07%, V28lung (α/β=9) – 21.64%; Dmean lung 11.72 Gy). V25lung (α/β=3.1) - р=0.438, V28lung (α/β=9) – р=0.461; Dmean lung р=0.2964. Based on our investigation, the lowest doses per ipsilateral lung were received in prone position with tidal respiration including axillary lymph nodes (LN) in MG volume. These findings were associated with the results of few international studies. No statistically significant difference in left lung radiation exposure was detected during the comparison of STR and DBH methods with the additional irradiation of supraclavicular and infraclavicular LN.

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