Vol. 2, 2017



N. M. Hovhannisyan, A. G. Karapetyan, V. S. Grigoryan

Pages: 1-5

DOI: 10.21175/RadProc.2017.01

The aim of the current research was to detect and assess the cytogenetic disorders of disaster fighters of Chernobyl nuclear power plant catastrophe, depending on radiation and non-radiation factors in the early and distant post-disaster periods with the help of system analysis methods. One can come across works dedicated to the study of genetic disorders of organisms exposed to a high level of radiation, but there are not enough data about the changes in these indices in case of low level radiation (lower than 1 Gy). This is the reason why it is of interest to find out the role of cytogenetic indices in the development of radiobiological effects in case of low dosage exposure. The results of regression, factorial dispersive multi regression and discriminant analyses methods of cytogenetic indices are presented in the study.
  1. J. B. Little, “Genomic instability and radiation,” Journal of Radiological Protection, vol. 23, no. 2, pp. 173-181, Jun. 2003.
    DOI: 10.1088/0952-4746/23/2/304
    PMid: 12875549
  2. K. Suzuki, M. Ojima, S. Kodama, M. Watanabe, “Radiation-induced DNA damage and delayed induced genomic instability,” Oncogene, vol. 22, no. 45, pp. 6988–6993, Oct. 2003.
    DOI: 10.1038/sj.onc.1206881
    PMid: 14557802
  3. W. Han, K. N. Yu, “Ionizing Radiation, DNA Double Strand Break and Mutation,” Advances in Genetics Research, vol. 4, pp. 1-13, Jan. 2010.
    Retrieved from: https://www.researchgate.net/publication/266462167_Ionizing_Radiation_DNA_Double_Strand_Break_and_Mutation
    Retrieved on: Feb 2, 2017.
  4. E. S. Gilbert, “Ionizing Radiation and Cancer Risks,” International Journal Radiation Biology, vol. 85, no. 6, pp. 467–482, Jun. 2009.
    DOI: 10.1080/09553000902883836
    PMid: 19401906
    PMCid: PMC2859619
  5. R. B. Richardson, “Ionizing radiation and aging: rejuvenating an old idea,” Aging (Albany NY), vol. 1, no. 11, pp.887-902, Nov. 2009.
    DOI: 10.18632/aging.100081
    PMid: 20157573
    PMCid: PMC2815743
  6. M. Nakano, Y. Kodama, K. Ohtaki, M. Itoh, R. Delongchamp, A. Awa et al., “Detection of stable chromosome aberrations by FISH in A-bomb survivors: Comparison with previous solid Giemsa staining data on the same 230 individuals,” Int. J. Radiation Biology, vol. 77, no. 9, pp.971–977, Sep. 2001.
    DOI: 10.1080/09553000110050065
    PMid: 11576457
  7. K. Breger, L. Smith, M. Turker, M. Trayer, “Ionizing radiation induces frequent translocations with delayed replication and condensation,” Cancer Res., vol. 64, no. 22, pp.8231-8238, Nov. 2004.
    DOI: 10.1158/0008-5472.CAN-04-0879
    PMid: 15548689
  8. B. R. Scott, K. M. Gott, C. A. Potter, J. Wilder, “A Comparison of in vivo cellular responses to Cs-137 Gamma Rays and 320-Kv X-rays,” Dose Response, vol. 11, no. 4, pp. 459–474, Nov. 2013.
    DOI: 10.2203/dose-response.12-050.Scott
    PMid: 24298223
    PMCid: PMC3834739
  9. Н. Д. Окладникова, Б. Р. Скотт, З. Б. Токарская, Г. В. Жунтова, В. Ф. Хохряков, В. А. Сырчиков, Е. С. Григорьева, “Уровень нестабильных и стабильных хромосомных аберраций при инкорпорации нетранспортабельных соединений плутония-239,” Медицинская радиология и радиационная безопасность, т. 50, № 6, с. 23-32, 2005. (N. D. Okladnikova, B. R. Scott, Z. B. Tokarskaya, G. V. Zhuntova, V. F. Khokhryakov, V. A. Syrchikov, E. S. Grigoryeva, “Evaluation of Genome Stability at Incorporation of Non-Transpose Compounds of Pu-239,” Medical Radiology and Radiation Safety, vol. 50, no. 6, pp. 23-32, 2005.)
  10. Cryptogenic Analysis for Radiation Dose Assessment, 1st ed., IAEA, Vienna, Austria, 2001, pp. 1-88.
    Retrieved from: http://www-pub.iaea.org/MTCD/publications/PDF/TRS405_scr.pdf
    Retrieved on: Jan. 24, 2017.
  11. В. П. Боровиков, “Классификация данных в системе STATISTICA – модуль Discriminant Analysis,” в Популярное введение в программу STATISTICA, 1-е издание, Москва, Россия: КомпьютерПресс, 1998, гл. 5, с. 163-185 (V. P. Borovikov, “Classification of data in Statistica system – Discriminant Analysis module,” in Popular introduction to the program STATISTICA, 1st ed., Moscow, Russia: ComputerPress, 1998, ch. 5, pp. 163-185.)
  12. Э. А. Вуколов, “Дисперсионный анализ,” “Регрессионный анализ,” в Основы статистического анализа, 2-е издание, Москва, Россия: Форум, 2008, гл. 5-6, с. 150-240. (E. A. Vukolov, “Dispersive analysis,” “Regression analysis,” in Fundamentals of statistical analysis, 2nd ed., Moscow, Russia: Forum, 2008, ch. 5-6, pp. 150-240.)
  13. J. S. Bedford, D. Phil, “Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations,” Int. J. Radiat. Oncol. Biol. Phys., vol. 21, no. 6, pp. 1457-1469, Nov. 1991.
    DOI: 10.1016/0360-3016(91)90320-4
  14. Н. Л. Шмакова, Е. А. Насонова, Е. А. Красавин, Л. А. Мельникова, Т. А. Фадеева, “Индукция хромосомных аберраций и микроядер в лимфоцитах периферической крови человека при действии малых доз облучения,” Радиационная биология. Радиоэкология, т. 46, № 4, с. 480-487, 2006. (N. L. Shmakova, E. A. Nasonova, E. A. Krasavin, L. A. Melnikova, T. A. Fadeeva, “Induction of Chromosome Aberrations and Micronuclei in Human Peripheral Blood Lymphocytes at Low Dose of Radiation,” Radiation biology. Radioecology, vol. 46, no. 4, pp. 480-487, 2006.)
  15. V. Yu. Kravtsov, R. F. Fedortseva, Ye. V. Starkova, N. M. Yartseva, A. M. Nikiforov, “Tailed nuclei and dicentric chromosomes in irradiated subjects,” Appl. Radiat. Isot., vol. 52, no. 2, pp. 1121-1127, May 2000.
    Retrieved from: www.sciencedirect.com/science/article/pii/S0969804300000579?via%3Dihub
    Retrieved on: Jan. 21, 2017
  16. V. Gorbunova, A. Seluanov, Z. Mao, C. Hine, “Changes in DNA repair during aging,” Nucleic Acids Res., vol. 35, no. 22, pp. 7466–7474, Dec. 2007.
    DOI: 10.1093/nar/gkm756
    PMid: 17913742
    PMCid: PMC2190694
  17. S. M. Gollin, “Acquired chromosome abnormalities: the cytogenetics of cancer,” in Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, vol. 1, L. Jorde, P. Little, M. Dunn, S. Subramaniam, Eds., 1st ed., John Wiley and Sons, 2005, ch. 1, sec. 2, pp. 1-14.
    DOI: 10.1002/047001153X.g102204