Vol. 2, 2017

Original research papers

Biophysics

OPTICAL SPECIFICITY OF THIN SHELL FOR NANO-DELIVERY MODEL

Ana J. Šetrajčić-Tomić, Ljubiša D. Džambas, Jovan P. Šetrajčić, Matilda Vojnović, Igor J. Šetrajčić

Pages: 283-289

DOI: 10.21175/RadProc.2017.57

The subject of the research in this paper includes theoretical investigation of nanomaterials modeling in the field of pharmaceutical technology for biomedical application. This includes a very precise encapsulated drug delivery, on exactly defined place in the human tissue or organ and a disintegration of capsule – drug carrier, so that the medicament can start producing its effect. The goal of multidisciplinary researches with biocompatible molecular nanomaterials is to find the parameters and the possibilities to construct boundary surfaces that will, in interaction with biological environment, create such properties of nanolayers that are convenient for use for layers of drug carrier capsules, biochips and biomarkers. These layers should demonstrate controlled disintegration of structure, better dielectric properties, discrete luminescence and appropriate bioporosity as all these are the requirements of contemporary nanomedicine. The main advantage of the theoretical approach is the essential knowledge of the mechanisms that allow us to comprehend the experimental conditions that we have to fulfill to be able to get the desired results. The results achieved up to now by our research group in the application of the Green's function method on flat ultrathin films are promising for applications in the frame of optical core-shell models. This paper presents the review of our current achievement in the field of theoretical physics of exciton ultrathin films and possible ways to materialize the same in the field of nanopharmacy.
  1. J. P. Šetrajčić, A. J. Šetrajčić–Tomić, Lj. D. Džambas and I. Gušić, “Core-shell layered models of nanostructured carriers for a nano-bio-medical applications,” in Proc. of 3rd International Conference on Radiation and Applications in Various Fields of Research, Budva, Montenegro, 2015, pp. 487-494.
    Retrieved from: http://www.rad-conference.org/helper/download.php?file=../pdf/Proceedings%20RAD%202015.pdf
    Retrieved on: Feb. 8, 2016.
  2. A. Ј. Šetrajčić-Tomić, Lj. D. Džambas, D. Lj. Džambas and J. P. Šetrajčić, “Optical Core-Shell Model for Nano-Delivery Applications,” in Proc. of 4th International Conference on Radiation and Applications in Various Fields of Research, Niš, Serbia, 2016, pp. 165-170.
    DOI: 10.21175/RadProc.2016.39
  3. K. J. Morrow Jr., R. Bawa, C. Wei, “Recent advances in basic and clinical nanomedicine,” Med. Clin. N. Am, vol. 91, no. 5, pp. 805-843, Sep. 2007.
    DOI: 10.1016/j.mcna.2007.05.009
    PMid: 17826104
  4. Drug Delivery Nanoparticles: Formulation and Characterization, vol. 191, Y. Pathak, D. Thassu, Eds., 1st ed., New York (NY), USA: Informa Healthcare USA Inc., 2009.
    Retrieved from: http://file.zums.ac.ir/ebook/231-Drug%20Delivery%20Nanoparticles%20Formulation%20and%20
    Characterization,%20Vol.%202-Yashwant%20Pathak%20%20Deepak%20.pdf

    Retrieved on: Jan. 16, 2017.
  5. H. E. Schaefer, Nanoscience – The science of the small in physics, engineering, chemistry, biology and medicine, vol. 1, 1st ed., Berlin, Germany: Springer, 2010.
    DOI: 10.1007/978-3-642-10559-3
  6. M. A. Greenwood, “Are Quantum Dots on the Brink of Their Big Break?” Photonic Spectra, vol. 41, no. 5, May 2007.
    Retrieved from: www.photonics.com/Article.aspx?AID=29421
    Retrieved on: Jan. 14, 2017.
  7. E. A. Murphy, B. K. Majeti, L. A. Barnes, M. Makale, S. M. Weis, K. Lutu-Fuga, W. Wrasidlo, D. A. Cheresh, “Nanoparticle-Mediated Drug Delivery to Tumor Vasculature Suppresses Metastasis,” Proc. Natl. Acad. Sci. USA, vol. 105, no. 27, pp. 9343-9348, July 2008.
    DOI: 10.1073/pnas.0803728105
    PMid: 18607000
    PMCid:PMC2453735
  8. W. C. W. Chan, “Bionanotechnology Progress and Advances,” Biol. Blood Marrow Transplant, vol.12, no. 1, pp. 87-91, Jan. 2006.
    DOI: 10.1016/j.bbmt.2005.10.004
    PMid: 16399591
  9. Y. Pathak, “Recent Developments in Nanoparticulate Drug Delivery Systems,” in Drug Delivery Nanoparticles: Formulation and Characterization, Y.Pathak, D.Thassu, Eds., 1st ed., New York (NY), USA: Informa Healthcare USA Inc., 2009, ch. 1, pp.1-15.
    Retrieved from: http://file.zums.ac.ir/ebook/231-Drug%20Delivery%20Nanoparticles%20Formulation%20and%20
    Characterization,%20Vol.%202-Yashwant%20Pathak%20%20Deepak%20.pdf

    Retrieved on: Jan. 16, 2017.
  10. H. Devapally, A. Chakilam, M. M. Amiji, “Role of Nanotechnology in Pharmaceutical Product Development,” J. Pharm. Sci., vol. 96, no. 10, pp. 2547–2565, Oct. 2007.
    DOI: 10.1002/jps.20875
    PMid: 17688284
  11. J. P. Šetrajčić, “Exact Microtheoretical Approach to Calculation of Optical Properties of Ultralow Dimensional Crystals,” arXiv: 1004.2387 [cond-mat.mtrl-sci], April 2010.
    Retrieved from: https://arxiv.org/abs/1004.2387
    Retrieved on: Jan. 12, 2017.
  12. J. P. Šetrajčić, S. S. Pelemiš, S. M. Vučenović, V. M. Zorić, S. Armaković, B. Škipina, A. J. Šetrajčić, “Absorption Features of Symmetric Molecular Nanofilms,” in IEEE Proceedings 27th International Conference on Microelectronics, Niš, Serbia, 2010, vol. 1, pp. 127-130.
    Retrieved from: http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=5483038.
    Retrieved on: Jan. 12, 2017.
  13. B. Škipina, D. Lj. Mirjanić, S. M. Vučenović, J. P. Šetrajčić, I. J. Šetrajčić, A. J. Šetrajčić-Tomić, S. S. Pelemiš, B. Markoski, “Selective IR Absorption in Molecular Nanofilms,” Optical Materials, vol. 33, no. 11, pp. 1578-1584, Sep. 2011.
    DOI: 10.1016/j.optmat.2011.04.008
  14. I. J. Šetrajčić, D. Rodić, J. P. Šetrajčić, “Optical Properties of Layers of Symmetric Molecular Nanofilms,” J. Opt., vol. 44, no. 1, pp. 1–6, Mar. 2015.
    DOI: 10.1007/s12596-014-0231-8
  15. J. P. Šetrajčić, D. Rodić, V. D. Sajfert, N. Pop, M. D. Popov, “Confinement Consequences on Optics of Molecular Crystalline Nanofilms,” Quantum Matter, vol. 6, no. 1, pp. 1–3, Feb. 2017.
    DOI: 10.1166/qm.2017.1392 .
  16. Su Y. Quek, J. B. Neaton, M. S. Hybertsen, E. Kaxiras, S. G. Louie, “First-principles Studies of the Electronic Structure of Cyclopentene on Si(001): Density Functional Theory and GW Calculations,” Phys. Stat. Solidi (b), vol. 243, no. 9, pp. 2048-2053, Jul. 2006.
    DOI: 10.1002/pssb.200666819
  17. G. Samsonidze, M. Jain, J. Deslippe, M. L. Cohen, S. G. Louie, “Simple Approximate Physical Orbitals for GW Quasiparticle Calculations,” Phys. Rev. Lett., vol. 107, no. 18, p. 186404, Oct. 2011.
    DOI: 10.1103/PhysRevLett.107.186404
    PMid: 22107653
  18. J. Deslippe, G. Samsonidze, D. A. Strubbe, M. Jain, M. L. Cohen, S. G. Louie, “BerkeleyGW: A Massively Parallel Computer Package for the Calculation of the Quasiparticle and Optical Properties of Materials and Nanostructures,” Comput. Phys. Commun., vol. 183, no. 6, pp. 1269-1289, Jun. 2012.
    DOI: 10.1016/j.cpc.2011.12.006
  19. G. Mahan, Many Particle Physics, 3rd ed., New York (NY), USA: Springer, 2000.
    DOI: 10.1007/978-1-4757-5714-9
  20. J. P. Šetrajčić, D. Lj. Mirjanić, S. M. Vučenović, D. I. Ilić, B. Markoski, S. K. Jaćimovski, V. D. Sajfert, V. M. Zorić, “Phonon Contribution in Thermodynamics of Nano-Crystalline Films and Wires,” Acta Phys. Pol. A, vol. 115, no. 4, pp. 778-782, Apr. 2009.
    DOI: 10.12693/APhysPolA.115.778
  21. S. M. Stojković, D. Lj. Mirjanić, J. P. Šetrajčić, D. D. Šijačić, I. K. Junger, “Spectra and States of Electrons in Surface Perturbed Quantum Wires,” Surface Science, vol. 477, no. 2-3, pp. 235-242, April 2001.
    DOI: 10.1016/S0039-6028(01)00887-1
  22. D. I. Ilić, S. M. Vučenović, S. K. Jaćimovski, V. M. Zorić, J. P. Šetrajčić, “Phonon Spectra and Thermodynamics of Crystalline Nanowires, in Low-Dimensional Materials Synthesis, Assembly, Property Scaling, and Modeling,” Mater. Res. Soc. Proc., vol. 1017, pp. 1-6, Jan. 2007.
    DOI: 10.1557/PROC-1017-DD08-50
  23. I. D. Vragović, J. P. Šetrajčić, R. Scholz, “Quantum Size Effects in the Optical Properties of Organic Superlattices Containing 3,4,9,10 PTCDA,” Eur. Phys. J. B, vol. 66, no. 2, pp. 185-190, Nov. 2008.
    DOI: 10.1140/epjb/e2008-00409-1
  24. J. P. Šetrajčić , S. K. Jaćimovski, “Review of Results of Theoretical Approaches to Phonon Engineering of Thermodynamic Properties for Different Quantum Structures,” NBP, vol. 20, no. 3, pp. 67-82, 2015 .
    DOI: 10.5937/NBP1503067J
  25. J. P. Šetrajčić, “Research of Properties of Nanoscopic Structures,” Zaštita materijala, vol. 57, no. 1, pp. 81-92, 2016.
    Retrieved from: http://www.readcube.com/articles/10.5937/ZasMat1601081S
    Retrieved on: Jan. 13, 2017.
  26. J. P. Šetrajčić, V. D. Sajfert, S. K. Jaćimovski, “Fundamental Preferences of the Phonon Engineering for Nanostructural Samples,” Rev. Theor. Sci., vol. 4, no. 4, pp. 353-401, Dec. 2016.
    DOI: 10.1166/rits.2016.1067
  27. G. Samsonidze, F. J. Ribeiro, M. L. Cohen, S. G. Louie, “Quasiparticle and Optical Properties of Polythiophene-Derived Polymers,” Phys. Rev. B, vol. 90, no. 3, p. 035123 Jul. 2014.
    DOI: 10.1103/PhysRevB.90.035123
  28. D. Lj. Mirjanić, J. P. Šetrajčić, Lj. D. Džambas, V. D. Mirjanić, A. J. Šetrajčić – Tomić, V. M. Zorić, “Nanoscopic Bio­materials in Medicine, Dentistry and Pharmacy,” presented at the 10th International Scientific-Practical Conference: Research, Development and Application of High Technologies in Industry, Saint-Petersburg, Russia, 2010.
  29. J. P. Šetrajčić, D. Lj. Mirjanić, A. J. Šetrajčić-Tomić, S. Armaković, I. J. Šetrajčić, “Core-Shell Nanomodels for Biomedical Applications,” in Proc. International Conference – New face of TMCR: Modern Technologies, Quality and Innovation, Chisinau, Moldova, 2011, pp. 545-548.
  30. J. P. Šetrajčić, D. Rodić, A. Ј. Šetrajčić-Tomić, S. M. Vučenović, “Resonant Optical Occurrences in Molecular Nanofilms”, Proc. 8th Internationl Conference: Contemporary Materials, Banja Luka, Rep. Srpska, 2016, pp. 71-78.